The revolution started in 1994 at New York’s Rockefeller University, when Dr. Jeffrey Friedman and his research team discovered that the fat cells of genetically obese mice failed to produce a chemical called LEPTIN. Leptin was the first adipokine, the first hormone shown to be made exclusively by fat cells. Researchers soon discovered that administration of leptin curbed the appetite and stimulated the metabolism of laboratory animals. Injecting leptin into genetically obese mice restored them to normal body weight. Leptin appeared to function as part of what scientists refer to as a negative feedback loop. When an animal is overfed and begins to gain weight, the increase in body fat leads to an increase in production of leptin, which in turn suppresses appetite and stimulates fat burning, restoring the animal to a normal lean weight. This process of internal self-correction is called "homeostasis" and it stabilizes the body’s internal state.
Overweight humans are not leptin deficient: the more body fat, the higher the levels of leptin in blood. For people who are chronically overweight, the problem seems to be that leptin is not doing its job of reducing appetite and stimulating fat burning. The effect of leptin is blocked. Scientists call this state LEPTIN RESISTANCE. Leptin resistance makes losing weight difficult if not impossible. The goal of The Fat Resistance Diet is to help readers overcome leptin resistance through a diet and exercise plan based on health research.